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SELECT 
  1 
FROM 
  csscart_lock_keys 
WHERE 
  key_id = 'f1a2a4dcc325242fa0ed85df89bf340801f421699e38db1ad7eeaad445efd293' 
  AND token = 'XICctfyL2Uwrp7f8tzHeqI+O5CbXxH0dffRMNahKPmA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}