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SELECT 
  1 
FROM 
  csscart_lock_keys 
WHERE 
  key_id = '4d52b13a639dd6e6fa107c7225e818e65836a7ca05bf0cd6d9c52d1f8825609e' 
  AND token = 'em/41cs7mxHCzKA34QQXG8WdtMV+9d9Mw+hHe6E0Vws=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}